Postpartum progression of chronic kidney disease in patients with chronic glomerulonephritis

Background: In the recent years, pregnancy outcomes in women with primary chronic glomerulonephritis (CGN) have been encouraging despite increased incidence of complications and preterm birth. However, impact on CKD progression remains understudied.
 Aim: To evaluate effect postpartum period patients CGN.
 Materials methods: This was an observational longitudinal study. The study group included 40 CGN G1G3b, who had deliveries from January 2009 to November 2022. control 35 no pregnancies after diagnosed. Serum creatinine estimated glomerular filtration rate (GFR) were assessed during follow up, recording development G5.
 Results: annual GFR decline -4.6 [-8.0; -2.5] ml/min/1.73 m2, -1.8 [-5.8; +1.5] m2 (p = 0.056). After complicated (preeclampsia, placental insufficiency, increase proteinuria, worsening arterial hypertension, acute kidney injury), -6.4 [-13.4; -3.5] which higher than controls 0.042). There significant differences survival without decrease by 30%, 50% G5 between groups. G5-free lower that 0.022) those uncomplicated 0.009).
 Eleven (11) main 3/35 reached G5. time delivery 4.83 [2.08; 7.07] years. Among end-stage renal failure childbirth, there significantly more G3, proteinuria 1 g/day pregnancy, hypertension at baseline preeclampsia, injury, less 37 weeks gestation, neonates requiring treatment intensive care unit, unfavorable outcomes.
 Conclusion: Renal pregnant not different did pregnancies; however, function decline.